Novel management of the microphthalmic orbit in a patient with PHACE syndrome

Ophthalmic Plast Reconstr Surg. 2011 Nov-Dec;27(6):e156-8. doi: 10.1097/IOP.0b013e318208319d.

Abstract

A full-term female infant with severe unilateral microphthalmos and ipsilateral orbital hemangioma in the setting of PHACE syndrome was successfully managed with oral propranolol therapy and subsequent orbital conformer placement. After 3 months of systemic propranolol therapy, the orbital hemangioma had shown significant regression without systemic or local complications. The authors believe this to be the first reported use of systemic propranolol therapy in the management of a hemangioma within a microphthalmic orbit of a patient with PHACE syndrome.

Publication types

  • Case Reports

MeSH terms

  • Administration, Oral
  • Aortic Coarctation / diagnosis
  • Aortic Coarctation / therapy*
  • Eye Abnormalities / diagnosis
  • Eye Abnormalities / therapy*
  • Facial Neoplasms / drug therapy
  • Facial Neoplasms / pathology
  • Female
  • Hemangioma / drug therapy
  • Hemangioma / pathology
  • Humans
  • Infant
  • Magnetic Resonance Imaging
  • Microphthalmos / diagnosis
  • Microphthalmos / therapy*
  • Neurocutaneous Syndromes / diagnosis
  • Neurocutaneous Syndromes / therapy*
  • Orbit / abnormalities*
  • Orbital Neoplasms / drug therapy
  • Orbital Neoplasms / pathology
  • Propranolol / therapeutic use*
  • Tissue Expansion / methods*
  • Tissue Expansion Devices*

Substances

  • Propranolol

Supplementary concepts

  • PHACE association