Gestational trophoblastic neoplasia (GTN) constitutes a spectrum of benign and malignant diseases that are associated with conception. The majority of patients with a benign GTN (hydatidiform mole) spontaneously enter remission after evacuation; however, 15% to 20% will develop a malignant form of GTN. The malignant GTN are classified as nonmetastatic GTN and metastatic GTN. Chemotherapy is the mainstay of treatment for malignant GTN. Patients require continuous emotional support during intense medical therapy because of issues related to the treatment and future pregnancies.