Benign cutaneous neural tumors

Semin Diagn Pathol. 2013 Feb;30(1):45-57. doi: 10.1053/j.semdp.2012.01.008.

Abstract

Benign cutaneous neural neoplasms are one of the most frequent benign mesenchymal tumors in the skin. Because peripheral sheath nerve is composed of different cells, the tumors raised in these structures are varied and usually contain many of these cells. Most of these tumors are easy to diagnose, as usually present characteristic features well-recognized and express -specific immunohistochemical proteins. However, there are so many infrequent variants that many times require distinction from others spindle-cell tumors including melanoma. The tumors differ from one another by displaying a different proportion and arrangement of the various constituents of a peripheral nerve. In this article, we present the most characteristic clinical and histopathological features of many of these frequent benign cutaneous neural tumors including their uncommon variants.

Publication types

  • Review

MeSH terms

  • Biomarkers, Tumor / metabolism
  • Biopsy
  • Hamartoma / metabolism
  • Hamartoma / pathology
  • Humans
  • Lipomatosis / metabolism
  • Lipomatosis / pathology
  • Myxoma / metabolism
  • Myxoma / pathology
  • Nerve Sheath Neoplasms / metabolism
  • Nerve Sheath Neoplasms / pathology*
  • Neurilemmoma / metabolism
  • Neurilemmoma / pathology
  • Neurofibroma / metabolism
  • Neurofibroma / pathology
  • Peripheral Nervous System Diseases / metabolism
  • Peripheral Nervous System Diseases / pathology
  • Skin / metabolism
  • Skin / pathology
  • Skin Neoplasms / metabolism
  • Skin Neoplasms / pathology*

Substances

  • Biomarkers, Tumor