Abstract
We report a case of non-immune hydrops fetalis (NIHF) caused by herpes simplex virus type 2 (HSV-2) in an infant whose mother had recurrent HSV-2 infection. In spite of prematurity, severe disseminated infection and hydrops, the infant survived and was neurologically intact. HSV-2-induced NIHF is extremely rare, particularly in the setting of recurrent maternal infection, and this case is, to our knowledge, the first report of a surviving infant. HSV-2 should be considered in the differential diagnosis of NIHF and early initiation of empiric acyclovir therapy is recommended in this setting, pending the results of virologic diagnostic tests.
Publication types
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Case Reports
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Research Support, N.I.H., Extramural
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Review
MeSH terms
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Acyclovir / therapeutic use
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Antiviral Agents / therapeutic use
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Extraembryonic Membranes / pathology
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Female
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Fetal Membranes, Premature Rupture / virology
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Herpes Genitalis / complications*
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Humans
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Hydrops Fetalis / drug therapy
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Hydrops Fetalis / virology*
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Infant, Newborn
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Infant, Premature
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Infant, Premature, Diseases / drug therapy
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Infant, Premature, Diseases / therapy
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Infant, Premature, Diseases / virology*
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Male
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Pregnancy
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Pregnancy Complications, Infectious / drug therapy
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Pregnancy Complications, Infectious / virology*
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Recurrence
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Young Adult
Substances
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Antiviral Agents
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Acyclovir