Are Hsp70 protein expression and genetic polymorphism implicated in multiple sclerosis inflammation?

Chiara Boiocchi; Cecilia Osera; Maria Cristina Monti; Ottavia Eleonora Ferraro; Stefano Govoni; Mariaclara Cuccia; Cristina Montomoli; Alessia Pascale; Roberto Bergamaschi

doi:10.1016/j.jneuroim.2014.01.004

Are Hsp70 protein expression and genetic polymorphism implicated in multiple sclerosis inflammation?

J Neuroimmunol. 2014 Mar 15;268(1-2):84-8. doi: 10.1016/j.jneuroim.2014.01.004. Epub 2014 Jan 16.

Authors

Chiara Boiocchi¹, Cecilia Osera², Maria Cristina Monti³, Ottavia Eleonora Ferraro³, Stefano Govoni², Mariaclara Cuccia⁴, Cristina Montomoli³, Alessia Pascale², Roberto Bergamaschi⁵

Affiliations

¹ Inter-department Multiple Sclerosis Research Centre, C. Mondino National Institute of Neurology Foundation, IRCCS, Pavia, Italy. Electronic address: chiara.boiocchi@unipv.it.
² Department of Drug Sciences, Section of Pharmacology, University of Pavia, Pavia, Italy.
³ Section of Biostatistics and Clinical Epidemiology, Department of Public Health, Experimental and Forensic Medicine, University of Pavia, Pavia, Italy.
⁴ Laboratory of Immunogenetics, Department of Biology & Biotechnology "L. Spallanzani", University of Pavia, Pavia, Italy.
⁵ Inter-department Multiple Sclerosis Research Centre, C. Mondino National Institute of Neurology Foundation, IRCCS, Pavia, Italy.

PMID: 24485944
DOI: 10.1016/j.jneuroim.2014.01.004

Abstract

Genetic and environmental factors contribute to disease Multiple Sclerosis (MS) susceptibility, the most prevalent neurological pathology affecting young individuals in Western countries. We focused our attention on HSP70-2, an inducible chaperon induced under stress conditions. Genotype analysis of HSP70-2 (+1267 A/G) polymorphism revealed a significant association between the minor allele G and presence of MS (OR:1.31, 95% CI: 1.02-1.69, P = 0.039). In addition, Hsp70-2 protein content in vitro from PBMC was significantly lower in MS patients with GG genotype compared to AA genotype, indicating an implication of the G allele of HSP70-2 gene polymorphism in the development of MS.

Keywords: HSP70-2 (+1267 A/G) polymorphism; Multiple Sclerosis; Neuroinflammation.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adult
Blotting, Western
Female
Genetic Predisposition to Disease*
Genotype
HSP70 Heat-Shock Proteins / genetics*
Humans
Inflammation / genetics
Inflammation / metabolism
Male
Multiple Sclerosis / genetics*
Multiple Sclerosis / metabolism*
Polymorphism, Restriction Fragment Length
Polymorphism, Single Nucleotide

Substances

HSP70 Heat-Shock Proteins
HSPA1B protein, human