Epidemiology of calcium pyrophosphate crystal arthritis and basic calcium phosphate crystal arthropathy

Abhishek Abhishek; Michael Doherty

doi:10.1016/j.rdc.2014.01.002

Epidemiology of calcium pyrophosphate crystal arthritis and basic calcium phosphate crystal arthropathy

Rheum Dis Clin North Am. 2014 May;40(2):177-91. doi: 10.1016/j.rdc.2014.01.002. Epub 2014 Feb 20.

Authors

Abhishek Abhishek¹, Michael Doherty²

Affiliations

¹ Department of Rheumatology, Box 204, Addenbrookes Hospital, Hills Road, Cambridge CB2 0QQ, UK; Academic Rheumatology, University of Nottingham, Nottingham NG5 1PB, UK. Electronic address: docabhishek@gmail.com.
² Academic Rheumatology, University of Nottingham, Nottingham NG5 1PB, UK.

PMID: 24703342
DOI: 10.1016/j.rdc.2014.01.002

Abstract

Calcium pyrophosphate crystal deposition (CPPD) is common and mainly associates with increasing age and osteoarthritis (OA). Recent studies suggest that CPPD occurs as the result of a generalized articular predisposition and may also associate with low cortical bone mineral density. The epidemiology of basic calcium phosphate (BCP) crystal deposition is poorly understood. Although periarticular BCP crystal deposits occurs at all ages and in both sexes, intra-articular BCP crystal deposition tends to associate with increasing age and OA. Calcium pyrophosphate and BCP crystals frequently coexist in joints with OA.

Keywords: Basic calcium phosphate crystal; Calcium pyrophosphate crystal; Calcium pyrophosphate crystal deposition; Epidemiology.

Publication types

Review

MeSH terms

Age Factors
Calcium Phosphates
Chondrocalcinosis / epidemiology*
Chondrocalcinosis / pathology
Hemochromatosis / epidemiology
Humans
Hyperparathyroidism / epidemiology
Hypophosphatasia / epidemiology
Magnesium / blood
Osteoarthritis / epidemiology*
Prevalence
Risk Factors
Sex Factors

Substances

Calcium Phosphates
Magnesium