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The Tsk2/+ mouse fibrotic phenotype is due to a gain-of-function mutation in the PIIINP segment of the Col3a1 gene.
J Invest Dermatol. 2015 Mar;135(3):718-27. doi: 10.1038/jid.2014.455. Epub 2014 Oct 20.
J Invest Dermatol. 2015.
PMID: 25330296
Free PMC article.
Type III collagen is a key regulator of the collagen fibrillar structure and biomechanics of articular cartilage and meniscus.
Wang C, Brisson BK, Terajima M, Li Q, Hoxha K, Han B, Goldberg AM, Sherry Liu X, Marcolongo MS, Enomoto-Iwamoto M, Yamauchi M, Volk SW, Han L.
Wang C, et al.
Matrix Biol. 2020 Jan;85-86:47-67. doi: 10.1016/j.matbio.2019.10.001. Epub 2019 Oct 23.
Matrix Biol. 2020.
PMID: 31655293
Free PMC article.
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