Coexistence of homologous-type cervical carcinosarcoma with endometrioid-type G1 endometrial cancer: a case report with an immunohistochemical study

Int J Clin Exp Pathol. 2014 Sep 15;7(10):7191-5. eCollection 2014.

Abstract

Coexistence of two or even more independent primary tumors derived from the female genital tract organs is a unique event. The most common combination is the coexistence of synchronous tumors in the ovary and endometrium. In the present case study, we described a coincidence of homologous-type cervical carcinosarcoma (CS) with endometrioid-type G1 uterine adenocarcinoma (EC) arising on the basis of hyperplastic endometrium. A panel of immunohistochemical markers was applied, either in both CS components or in endometrioid-type EC, to assess possible differences between both uterine malignancies. We also presented a short overview of the coexistence of cervical carcinosarcomas with other female genital tract malignancies.

Keywords: Cervical carcinosarcoma; endometrial cancer; endometrial hyperplasia; immunohistochemisty.

Publication types

  • Case Reports
  • Comparative Study
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Biomarkers, Tumor / analysis*
  • Biopsy
  • Carcinoma, Endometrioid / chemistry*
  • Carcinoma, Endometrioid / pathology
  • Carcinoma, Endometrioid / therapy
  • Carcinosarcoma / chemistry*
  • Carcinosarcoma / pathology
  • Carcinosarcoma / therapy
  • Diagnosis, Differential
  • Endometrial Neoplasms / chemistry*
  • Endometrial Neoplasms / pathology
  • Endometrial Neoplasms / therapy
  • Female
  • Humans
  • Immunohistochemistry*
  • Middle Aged
  • Predictive Value of Tests
  • Treatment Outcome
  • Uterine Cervical Neoplasms / chemistry*
  • Uterine Cervical Neoplasms / pathology
  • Uterine Cervical Neoplasms / therapy

Substances

  • Biomarkers, Tumor