Prophylactic colectomy: Rationale, indications, and approach

J Surg Oncol. 2015 Jan;111(1):112-7. doi: 10.1002/jso.23820. Epub 2014 Nov 21.

Abstract

Discerning the genetics of hereditary colorectal cancer syndromes has enabled a more individualized approach to preventing and treating colorectal cancers in affected patients and families. As these syndromes carry significant risk of colorectal cancer (nearly 100% in some cases), prophylactic colectomy is an important option for preventing cancer. This article addresses the rationale and indications for prophylactic colectomy in hereditary colorectal cancer syndromes, and provides insight into the details of surgical management.

Keywords: Lynch syndrome; colorectal polyposis; familial adenomatous polyposis; hereditary colorectal cancer; prophylactic surgery.

Publication types

  • Review

MeSH terms

  • Colectomy*
  • Colonic Neoplasms / diagnosis
  • Colonic Neoplasms / prevention & control
  • Colonic Neoplasms / surgery*
  • Humans
  • Prophylactic Surgical Procedures*