Hypomelanosis of Ito: a round on the frequency and type of epileptic complications

Neurol Sci. 2015 Jul;36(7):1173-80. doi: 10.1007/s10072-014-2049-1. Epub 2015 Jan 14.

Abstract

There is an ample evidence that hypopigmentation of the skin along the Blaschko's lines is frequently associated with neurological disorders. Nowadays, the term "Hypomelanosis of Ito" (HI) is applied when, together with the cutaneous lesions, various and multisystem organs are involved. Among these, the most frequent are cerebral manifestations, such as cognitive delay and epileptic seizures. For this reason, hypomelanosis of Ito has been included in the group of neurocutaneous syndromes, neurologic manifestations being one of the most frequent. Epileptic seizures have been reported in patients with this disorder, but in a very few particular attention has been focused on the type and frequency of epilepsy and on the response to the treatment. Herein, we report on five patients with HI who showed episodes of epileptic seizures with onset in childhood, in absence of malformative anomalies except for the skin lesions. A survey on the frequency and types of epileptic seizures in HI children and in the literature is reported.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Adult
  • Child
  • Electroencephalography
  • Epilepsy / etiology*
  • Female
  • Humans
  • Hypopigmentation / complications*
  • Hypopigmentation / pathology
  • Magnetic Resonance Imaging
  • Male