Renal oligo- and anhydramnios: cause, course and outcome--a single-center study

Arch Gynecol Obstet. 2015 Aug;292(2):327-36. doi: 10.1007/s00404-015-3648-7. Epub 2015 Feb 13.

Abstract

Purpose: To evaluate the outcome of patients with renal oligohydramnios and explore the impact of patient variables on outcome and prognosis.

Methods: A retrospective single-center study was conducted analyzing 104 pregnancies complicated by oligohydramnios of renal origin from 2001 to 2011. Statistical analysis was performed to assess the influence of pre- and postnatal data on pregnancy outcome, morbidity and mortality.

Results: Prenatal renal diagnoses were as follows: hydronephrosis/megaureter: n = 21 (20.2 %), aberrance in renal form or location: n = 7 (6.7 %), cystic renal disease: n = 28 (26.9 %), renal dysplasia: n = 24 (23.1 %), renal agenesis: n = 42 (30.4 %), posterior urethral valves: n = 11 (10.6 %). Hydronephrosis/megaureter and late onset of oligohydramnios were prognostic factors for fetal survival, whereas renal agenesis and associated anomalies had a negative impact on pregnancy outcome. Prenatal interventions did not improve prognosis.

Conclusions: Pregnancies complicated by renal oligohydramnios still have a poor outcome. Careful weighing of prognostic factors is necessary to decide about further therapeutic measures.

MeSH terms

  • Abnormalities, Multiple / diagnostic imaging
  • Adult
  • Congenital Abnormalities
  • Female
  • Humans
  • Hydronephrosis / etiology*
  • Kidney / abnormalities
  • Kidney Diseases / congenital
  • Kidney Tubules, Proximal / abnormalities
  • Male
  • Oligohydramnios / etiology*
  • Pregnancy
  • Pregnancy Complications
  • Pregnancy Outcome
  • Prenatal Diagnosis / adverse effects
  • Prenatal Diagnosis / methods*
  • Prognosis
  • Retrospective Studies
  • Ultrasonography, Prenatal / methods*
  • Urogenital Abnormalities

Supplementary concepts

  • Allanson Pantzar McLeod syndrome
  • Hereditary renal agenesis
  • Renal Adysplasia