Skin manifestations of chronic kidney disease

Actas Dermosifiliogr. 2015 Oct;106(8):609-22. doi: 10.1016/j.ad.2015.05.007. Epub 2015 Jun 17.
[Article in English, Spanish]

Abstract

Skin manifestations associated with chronic kidney disease are very common. Most of these conditions present in the end stages and may affect the patient's quality of life. Knowledge of these entities can contribute to establishing an accurate diagnosis and prognosis. Severe renal pruritus is associated with increased mortality and a poor prognosis. Nail exploration can provide clues about albumin and urea levels. Nephrogenic systemic fibrosis is a preventable disease associated with gadolinium contrast. Comorbidities, such as diabetes mellitus and secondary hyperparathyroidism, can lead to acquired perforating dermatosis and calciphylaxis, respectively. Effective and innovative treatments are available for all of these conditions.

Keywords: Calcifilaxis; Calciphylaxis; Chronic kidney disease; Enfermedad renal crónica; Fibrosis sistémica nefrogénica; Nephrogenic systemic fibrosis; Porfiria cutánea tarda; Porphyria cutanea tarda.

Publication types

  • Review

MeSH terms

  • Calciphylaxis / etiology
  • Calciphylaxis / therapy
  • Comorbidity
  • Hair Diseases / etiology
  • Hair Diseases / pathology
  • Hair Diseases / therapy
  • Humans
  • Nail Diseases / etiology
  • Nail Diseases / pathology
  • Nail Diseases / therapy
  • Nephrogenic Fibrosing Dermopathy / etiology
  • Nephrogenic Fibrosing Dermopathy / therapy
  • Porphyria Cutanea Tarda / etiology
  • Porphyria Cutanea Tarda / therapy
  • Prognosis
  • Pruritus / etiology
  • Pruritus / therapy
  • Renal Insufficiency, Chronic / complications
  • Renal Insufficiency, Chronic / pathology*
  • Skin / pathology*
  • Skin Diseases / diagnosis
  • Skin Diseases / etiology*
  • Skin Diseases / pathology
  • Skin Diseases / therapy
  • Therapies, Investigational