Simple renal cyst and abdominal aortic aneurysm

J Vasc Surg. 2016 Jan;63(1):254-9.e1. doi: 10.1016/j.jvs.2015.08.095. Epub 2015 Oct 21.

Abstract

Objective: To summarize the association of simple renal cyst (SRC) with abdominal aortic aneurysm (AAA), we reviewed currently available clinical studies with a systematic literature search and meta-analytic evaluation.

Methods: To identify all case-control studies evaluating the association of SRC with AAA, databases including MEDLINE and Embase were searched through April 2015 using web-based search engines (PubMed and Ovid). For each study, data regarding SRC prevalence in both the AAA and control groups were used to generate unadjusted odds ratios (ORs) and 95% confidence intervals. When an adjusted OR (by the use of multivariable logistic regression) was available, we preferentially abstracted the adjusted OR rather than an unadjusted OR.

Results: Of 139 potentially relevant articles screened initially, 5 eligible case-control studies enrolling a total of 2897 participants were identified and included. A pooled analysis of seven estimates from the five studies demonstrated a statistically significant 2.54-fold prevalence of SRC in patients with AAA relative to subjects without AAA (OR, 2.54; 95% confidence interval, 1.93-3.34; P < .00001).

Conclusions: Our meta-analytic evaluation demonstrated 2.5-fold prevalence of SRC in patients with AAA relative to subjects without AAA, which suggests that SRC is associated with AAA.

Publication types

  • Meta-Analysis
  • Review

MeSH terms

  • Aortic Aneurysm, Abdominal / diagnosis
  • Aortic Aneurysm, Abdominal / epidemiology*
  • Chi-Square Distribution
  • Humans
  • Kidney Diseases, Cystic / diagnosis
  • Kidney Diseases, Cystic / epidemiology*
  • Logistic Models
  • Multivariate Analysis
  • Odds Ratio
  • Prevalence
  • Risk Factors