Incidence, risk factors and prognosis of postoperative atrial arrhythmias after lung transplantation: a systematic review and meta-analysis

Postoperative atrial arrhythmia is the most common dysrhythmia seen after lung transplantation. However, risk factors for postoperative atrial arrhythmias and their impact on outcomes were inconsistent. The aim of our study was to conduct a meta-analysis to analyse risk factors of postoperative atrial arrhythmias and the impact of postoperative atrial arrhythmias on outcomes after lung transplantation. All eligible articles from MEDLINE, EMBASE, CENTRAL and the Chinese BioMedical Literature Database (until November 2015) were incorporated into this study. We extracted the data from the included studies and performed a meta-analysis to evaluate predictors for postoperative atrial arrhythmias and their impact on outcomes. R software and STATA 13.0 software were used for the meta-analysis. A total of 2094 patients from 11 studies were included in this meta-analysis. The pooled incidence of postoperative atrial arrhythmias after lung transplantation was 31% [95% confidence interval (CI), 25-37%]. We found that gender (female versus male) with an odds ratio (OR) of 0.44 (95% CI 0.35-0.56, P < 0.001), age (>50 vs ≤50 or atrial arrhythmias versus non-atrial arrhythmias) with OR of 2.73 (95% CI 1.86-4.00, P < 0.001) and weighted mean difference (WMD) of 5.88 years (95% CI 3.69-8.07, P < 0.001), history of atrial arrhythmias with OR of 1.76 (95% CI 1.34-2.32, P = 0.002), vasopressor use with OR of 1.76 (95% CI 1.34-2.32, P < 0.001), cystic fibrosis with OR of 0.32 (95% CI 0.18-0.59, P < 0.001), interstitial lung disease with OR of 1.85 (95% CI 1.27-2.71, P = 0.001), hypertension with OR of 1.49 (95% CI 1.12-1.97, P = 0.006), coronary artery disease with OR of 1.58 (95% CI 1.20-2.08, P = 0.001), hyperlipidaemia with OR of 1.52 (95% CI 1.06-2.20, P = 0.025) and left atrial enlargement with OR of 2.99 (95% CI 1.91-4.67, P < 0.001) were significantly associated with postoperative atrial arrhythmias after lung transplantation. Postoperative atrial arrhythmias had a significant influence on length of stay (WMD 9.72, 95% CI 5.07-14.38, P < 0.001) and overall survival (OS) (hazard ratio 1.72, 95% CI 1.39-2.12, P < 0.001) after lung transplantation. In conclusion, the significant risk factors for postoperative atrial arrhythmias were gender, age, history of atrial arrhythmias, vasopressor use, cystic fibrosis, interstitial lung disease, hypertension, coronary artery disease, hyperlipidaemia, cardiac index and left atrial size. Development of postoperative atrial arrhythmias has prognostic implications for length of stay and overall survival after lung transplantation. Prospective and randomized trials are needed to address these issues in the future.