G protein pathway suppressor 2 (GPS2) acts as a tumor suppressor in liposarcoma

Tumour Biol. 2016 Oct;37(10):13333-13343. doi: 10.1007/s13277-016-5220-x. Epub 2016 Jul 26.

Abstract

Liposarcoma(LPS) is the most common type of soft tissue sarcoma accounting for 20 % of all adult sarcomas. However, the molecular pathogenesis of this malignancy is still poorly understood. Here, we showed that GPS2 expression was downregulated in LPS and correlated with the prognosis of this disease. In vitro study showed that knockdown of GPS2 resulted in enhanced proliferation and migration of LPS cell line SW872, without significant influence of cell death. Conclusively, our results suggest that GPS2 may act as a tumor suppressor in LPS and serve as a potential prognosis marker for this disease.

Keywords: DDLPS; GPS2; Liposarcoma; WDLPS.

MeSH terms

  • Adipogenesis
  • Adult
  • Aged
  • Aged, 80 and over
  • Apoptosis / genetics
  • Biomarkers
  • Cell Cycle / genetics
  • Cell Line, Tumor
  • Cell Movement / genetics
  • Cell Proliferation
  • Female
  • Follow-Up Studies
  • Gene Expression
  • Gene Knockdown Techniques
  • Humans
  • Immunohistochemistry
  • Intracellular Signaling Peptides and Proteins / genetics
  • Intracellular Signaling Peptides and Proteins / metabolism*
  • Liposarcoma / genetics
  • Liposarcoma / metabolism*
  • Liposarcoma / mortality
  • Liposarcoma / pathology
  • Male
  • Middle Aged
  • Prognosis
  • Signal Transduction
  • Tumor Suppressor Proteins / genetics
  • Tumor Suppressor Proteins / metabolism*

Substances

  • Biomarkers
  • GPS2 protein, human
  • Intracellular Signaling Peptides and Proteins
  • Tumor Suppressor Proteins