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ALS Mutations Disrupt Phase Separation Mediated by α-Helical Structure in the TDP-43 Low-Complexity C-Terminal Domain.
Structure. 2016 Sep 6;24(9):1537-49. doi: 10.1016/j.str.2016.07.007. Epub 2016 Aug 18.
Structure. 2016.
PMID: 27545621
Free PMC article.
The physical forces mediating self-association and phase-separation in the C-terminal domain of TDP-43.
Li HR, Chen TC, Hsiao CL, Shi L, Chou CY, Huang JR.
Li HR, et al.
Biochim Biophys Acta Proteins Proteom. 2018 Feb;1866(2):214-223. doi: 10.1016/j.bbapap.2017.10.001. Epub 2017 Oct 4.
Biochim Biophys Acta Proteins Proteom. 2018.
PMID: 28988034
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TAR DNA-binding protein 43 (TDP-43) liquid-liquid phase separation is mediated by just a few aromatic residues.
Li HR, Chiang WC, Chou PC, Wang WJ, Huang JR.
Li HR, et al.
J Biol Chem. 2018 Apr 20;293(16):6090-6098. doi: 10.1074/jbc.AC117.001037. Epub 2018 Mar 6.
J Biol Chem. 2018.
PMID: 29511089
Free PMC article.
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