Chemical-Induced Vitiligo

Dermatol Clin. 2017 Apr;35(2):151-161. doi: 10.1016/j.det.2016.11.006.

Abstract

Chemical-induced depigmentation of the skin has been recognized for more than 75 years, first as an occupational hazard but then extending to those using household commercial products as common as hair dyes. Since their discovery, these chemicals have been used therapeutically in patients with severe vitiligo to depigment their remaining skin and improve their appearance. Because chemical-induced depigmentation is clinically and histologically indistinguishable from nonchemically induced vitiligo, and because these chemicals appear to induce melanocyte autoimmunity, this phenomenon should be known as "chemical-induced vitiligo," rather than less accurate terms that have been previously used.

Keywords: Autoimmunity; Cellular stress; Chemical; Leukoderma; Monobenzone; Phenol; Rhododendrol; Vitiligo.

Publication types

  • Review

MeSH terms

  • Autoimmunity
  • Catechols / adverse effects
  • Hair Dyes / adverse effects*
  • Humans
  • Hydroquinones / adverse effects
  • Hypopigmentation / chemically induced*
  • Phenols / adverse effects*
  • Phenylenediamines / adverse effects
  • Skin Lightening Preparations / adverse effects*
  • Vitiligo / chemically induced*

Substances

  • Catechols
  • Hair Dyes
  • Hydroquinones
  • Phenols
  • Phenylenediamines
  • Skin Lightening Preparations
  • p-tert-butyl catechol
  • monobenzone
  • hydroquinone