Lynch Syndrome and Endometrial Cancer

South Med J. 2017 Apr;110(4):265-269. doi: 10.14423/SMJ.0000000000000633.

Abstract

In patients with Lynch syndrome, gynecologic cancer often can be the first presenting malignancy. In this review, we summarize the genetics of Lynch syndrome and review the various modalities of identifying patients at risk for this syndrome. The clinical characteristics of Lynch-associated endometrial cancer and screening and risk-reducing strategies also are described.

Publication types

  • Review

MeSH terms

  • Colorectal Neoplasms, Hereditary Nonpolyposis / complications*
  • Colorectal Neoplasms, Hereditary Nonpolyposis / etiology
  • Colorectal Neoplasms, Hereditary Nonpolyposis / genetics
  • Endometrial Neoplasms / etiology*
  • Endometrial Neoplasms / genetics
  • Female
  • Humans
  • Risk Factors