A centrosomal scaffold shows some self-control

J Biol Chem. 2017 Dec 15;292(50):20410-20411. doi: 10.1074/jbc.H117.806018.

Abstract

The scaffolding protein AKAP350A is known to localize to the centrosome and the Golgi, but the molecular details of its function at the centrosome remain elusive. Using structure-function analyses, protein interaction assays, and super-resolution microscopy, Kolobova et al. now identify AKAP350A's specific location and protein partners at the centrosome. The authors further define an autoregulatory mechanism that likely controls AKAP350A's ability to nucleate microtubule growth.

Publication types

  • Review

MeSH terms

  • A Kinase Anchor Proteins / chemistry
  • A Kinase Anchor Proteins / metabolism*
  • Animals
  • Cell Cycle Proteins
  • Centrosome / chemistry
  • Centrosome / metabolism*
  • Cytoskeletal Proteins / chemistry
  • Cytoskeletal Proteins / metabolism*
  • Humans
  • Intracellular Signaling Peptides and Proteins / chemistry
  • Intracellular Signaling Peptides and Proteins / metabolism
  • Microtubule-Associated Proteins / chemistry
  • Microtubule-Associated Proteins / metabolism
  • Microtubule-Organizing Center / chemistry
  • Microtubule-Organizing Center / metabolism*
  • Models, Molecular*
  • Nerve Tissue Proteins / chemistry
  • Nerve Tissue Proteins / metabolism
  • Phosphoproteins / chemistry
  • Phosphoproteins / metabolism
  • Protein Interaction Domains and Motifs
  • Protein Multimerization
  • Protein Transport

Substances

  • A Kinase Anchor Proteins
  • AKAP9 protein, human
  • CDK5RAP2 protein, human
  • CEP68 protein, human
  • Cell Cycle Proteins
  • Cep170 protein, human
  • Cytoskeletal Proteins
  • Intracellular Signaling Peptides and Proteins
  • Microtubule-Associated Proteins
  • Nerve Tissue Proteins
  • Phosphoproteins