Delayed Generalized Necrotic Purpuric Rash in a C6-deficient 12-year-old Girl Treated for Group W Meningococcal Disease

Pediatr Infect Dis J. 2018 Oct;37(10):1014-1015. doi: 10.1097/INF.0000000000001966.

Abstract

We report an unusual case of generalized necrotic purpuric rash that started 48 hours after the initiation of effective third-generation cephalosporin therapy to treat Neisseria meningitidis W infection in a 12-year-old girl. The course was favorable with no shock, and she recovered completely without sequelae. This infection revealed C6 deficiency in our patient.

Publication types

  • Case Reports

MeSH terms

  • Anti-Bacterial Agents / adverse effects*
  • Anti-Bacterial Agents / therapeutic use
  • Cephalosporins / adverse effects*
  • Cephalosporins / therapeutic use
  • Child
  • Complement C6 / deficiency*
  • Female
  • Hereditary Complement Deficiency Diseases
  • Humans
  • Immunologic Deficiency Syndromes / complications*
  • Meningococcal Infections / complications
  • Meningococcal Infections / drug therapy*
  • Necrosis / etiology
  • Neisseria meningitidis / drug effects
  • Purpura / etiology*

Substances

  • Anti-Bacterial Agents
  • Cephalosporins
  • Complement C6

Supplementary concepts

  • Complement Component 6 Deficiency