Mortality in Patients with Endogenous Cushing's Syndrome

Pedram Javanmard; Daisy Duan; Eliza B Geer

doi:10.1016/j.ecl.2018.02.005

Mortality in Patients with Endogenous Cushing's Syndrome

Endocrinol Metab Clin North Am. 2018 Jun;47(2):313-333. doi: 10.1016/j.ecl.2018.02.005.

Authors

Pedram Javanmard¹, Daisy Duan¹, Eliza B Geer²

Affiliations

¹ Department of Medicine, Division of Endocrinology, Diabetes, and Bone Disease, Icahn School of Medicine, The Mount Sinai Hospital, 1 Gustave L Levy Place, Box 1055, New York, NY 10029, USA.
² Division of Endocrinology, Department of Medicine, Multidisciplinary Pituitary and Skull Base Tumor Center, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, Box 419, New York, NY 10065, USA. Electronic address: geere@mskcc.org.

PMID: 29754634
DOI: 10.1016/j.ecl.2018.02.005

Abstract

Cushing's syndrome is associated with increased morbidity and mortality. Cardiovascular events, sepsis, and thromboembolism are the leading causes of mortality. Patient's with Cushing's due to a pituitary adenoma and those with Cushing's due to benign adrenal adenoma have relatively good survival outcomes often mirroring that of the general population. Persistent or recurrent disease is associated with high mortality risk. Ectopic Cushing's syndrome and Cushing's due to adrenocortical carcinoma confer the highest mortality risk among Cushing's etiologies. Prompt diagnosis and treatment, and specific monitoring for and treatment of associated comorbidities are essential to decrease the burden of mortality from Cushing's.

Keywords: Adrenal Cushing’s; Cushing’s disease; Cushing’s syndrome; Ectopic Cushing’s; Mortality; Subclinical Cushing’s.

Publication types

Review

MeSH terms

Adrenal Gland Neoplasms / complications
Adrenal Gland Neoplasms / mortality*
Cushing Syndrome / etiology
Cushing Syndrome / mortality*
Humans
Pituitary Neoplasms / complications
Pituitary Neoplasms / mortality*