IgG4-related orbital disease

Arch Soc Esp Oftalmol (Engl Ed). 2018 Oct;93(10):494-496. doi: 10.1016/j.oftal.2018.04.003. Epub 2018 Jun 1.
[Article in English, Spanish]

Abstract

Case report: The case is presented of a 64-year-old woman with bilateral palpebral swelling and dacryoadenitis, exophthalmos, and a history of chronic rhinitis and asthma. An increase in serum IgG4 was observed, and an incisional biopsy of lacrimal glands was performed, which showed fibrosis and a lymphoplasmacytic infiltrate with IgG4 producing cells.

Discussion: Orbital involvement in IgG4-related disease is frequent. Bilateral dacryoadenitis is the most common manifestation. Histopathology is essential for the diagnosis and to exclude malignancy.

Keywords: Dacrioadenitis; Dacryoadenitis; Enfermedad relacionada con IgG4; IgG4-related disease; Inflamación orbitaria inespecífica; Non-specific orbital inflammation; Orbit; Órbita.

Publication types

  • Case Reports

MeSH terms

  • Asthma / complications
  • Biopsy
  • Dacryocystitis / etiology*
  • Dacryocystitis / immunology
  • Dacryocystitis / pathology
  • Diagnosis, Differential
  • Exophthalmos / etiology
  • Female
  • Fibrosis
  • Humans
  • Immunoglobulin G4-Related Disease / complications
  • Immunoglobulin G4-Related Disease / diagnosis*
  • Immunoglobulin G4-Related Disease / pathology
  • Lacrimal Apparatus / immunology
  • Lacrimal Apparatus / pathology
  • Middle Aged
  • Orbital Diseases / complications
  • Orbital Diseases / diagnosis*
  • Orbital Diseases / immunology
  • Orbital Diseases / pathology
  • Orbital Neoplasms / diagnosis
  • Plasma Cells / pathology
  • Rhinitis / complications
  • Salivary Glands, Minor / pathology
  • Xerophthalmia / complications