Multimodal Imaging of Nonneovascular Age-Related Macular Degeneration

Invest Ophthalmol Vis Sci. 2018 Mar 20;59(4):AMD48-AMD64. doi: 10.1167/iovs.18-24158.

Abstract

Nonneovascular (dry) AMD is a retinal disease with potential for significant central visual impairment. The hallmarks of this disease are macular drusen, RPE alterations, and geographic atrophy (GA). Classification schemes for nonneovascular AMD have evolved over the years as major advances in retinal imaging have enabled a greater understanding of disease pathophysiology. The original classifications of nonneovascular AMD were based on color fundus photography (CFP), while more modern schemes rely on a multimodal imaging approach. Effective diagnosis and management of nonneovascular AMD requires a thorough understanding of its multimodal imaging features as detailed in this review. Future imaging modalities and imaging biomarkers that may aid in diagnosis and management are also discussed.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Coloring Agents / administration & dosage
  • Diagnostic Techniques, Ophthalmological*
  • Fluorescein Angiography
  • Geographic Atrophy / diagnostic imaging*
  • Humans
  • Indocyanine Green / administration & dosage
  • Infrared Rays
  • Multimodal Imaging / methods*
  • Optical Imaging
  • Photography
  • Retinal Drusen / diagnostic imaging*
  • Retinal Pigment Epithelium / diagnostic imaging*
  • Tomography, Optical Coherence

Substances

  • Coloring Agents
  • Indocyanine Green