Thyroid nodules and thyroid cancer discovered during pregnancy can result in significant anxiety for patients may present a challenge for providers. The prevalence of thyroid nodules is reported to vary between 3% and 21%. The estimated overall prevalence of thyroid cancer during pregnancy is 14.4 per 100,000 births. Imaging and possible tissue diagnosis should be considered for palpable thyroid nodules. Benign or stable nodules can usually be observed through pregnancy. Suspicious masses may require surgical treatment, best handled through multidisciplinary care. Clinicians should be aware of the care and management recommendations during the antepartum and postpartum periods.