Transgelin-2 contributes to proliferation and progression of hepatocellular carcinoma via regulating Annexin A2

Biochem Biophys Res Commun. 2020 Mar 12;523(3):632-638. doi: 10.1016/j.bbrc.2020.01.028. Epub 2020 Jan 12.

Abstract

Hepatocellular carcinoma (HCC) is one of the most common malignant tumors, but its pathogenesis is not clear. This study found that the expression of TAGLN2 mRNA and protein in HCC was higher than that in adjacent tissues. TCGA database analysis further confirmed this result, and found that the expression of TAGLN2 was positively correlated with the prognosis of HCC, suggesting that TAGLN2 may be a tumor promoter gene. Then the TAGLN2-Annexin A2 (ANXA2) interaction and NF-κB signaling pathway were further clarified during the invasion and metastasis of HCC. This mechanism provides a theoretical basis for further finding molecular targets and drug targets related to HCC metastasis.

Keywords: Annexin A2; Hepatocellular carcinoma; Progression; Proliferation; Transgelin-2.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Annexin A2 / analysis
  • Annexin A2 / genetics*
  • Carcinoma, Hepatocellular / diagnosis
  • Carcinoma, Hepatocellular / genetics*
  • Carcinoma, Hepatocellular / pathology
  • Cell Line, Tumor
  • Cell Proliferation
  • Disease Progression
  • Gene Expression Regulation, Neoplastic*
  • Humans
  • Liver Neoplasms / diagnosis
  • Liver Neoplasms / genetics*
  • Liver Neoplasms / pathology
  • Microfilament Proteins / analysis
  • Microfilament Proteins / genetics*
  • Middle Aged
  • Muscle Proteins / analysis
  • Muscle Proteins / genetics*
  • Prognosis
  • Up-Regulation

Substances

  • ANXA2 protein, human
  • Annexin A2
  • Microfilament Proteins
  • Muscle Proteins
  • Tagln2 protein, human