Abstract
Combined antituberculosis substances induced a dose-dependent changes in activity of dehydrogenases and hydrolases in rat lymphocytes. The main toxic effect of the substances was related to inhibition of mitochondrial dehydrogenases (succinate dehydrogenase and α-glycerol phosphate dehydrogenase) usually followed by suppression of activity of hydrolytic enzymes (acid phosphatase and non-specific esterase). Opposite changes in lactate dehydrogenase activity reflected specific features of intoxication.
Keywords:
antituberculosis substances; dehydrogenases; hydrolases; lymphocytes; toxic effects.
MeSH terms
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Acid Phosphatase / genetics
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Acid Phosphatase / metabolism
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Administration, Oral
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Animals
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Animals, Outbred Strains
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Antitubercular Agents / toxicity*
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Drug Combinations
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Esterases / genetics
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Esterases / metabolism
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Ethambutol / toxicity*
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Fluoroquinolones / toxicity*
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Gene Expression / drug effects
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Glycerolphosphate Dehydrogenase / antagonists & inhibitors
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Glycerolphosphate Dehydrogenase / genetics
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Glycerolphosphate Dehydrogenase / metabolism
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Isoniazid / toxicity*
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L-Lactate Dehydrogenase / genetics
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L-Lactate Dehydrogenase / metabolism
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Lymphocytes / cytology
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Lymphocytes / drug effects*
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Lymphocytes / enzymology
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Male
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Primary Cell Culture
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Prothionamide / toxicity*
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Pyrazinamide / toxicity*
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Rats
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Rifampin / toxicity*
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Succinate Dehydrogenase / antagonists & inhibitors
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Succinate Dehydrogenase / genetics
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Succinate Dehydrogenase / metabolism
Substances
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Antitubercular Agents
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Drug Combinations
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Fluoroquinolones
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Pyrazinamide
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Prothionamide
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Ethambutol
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Glycerolphosphate Dehydrogenase
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L-Lactate Dehydrogenase
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Succinate Dehydrogenase
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Esterases
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Acid Phosphatase
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lomefloxacin
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Isoniazid
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Rifampin