Hyperkalemic periodic paralysis aggravated by voltage - gate sodium channel blocker antiepileptic drug?

S Zukić; O Sinanović; M Alečković-Halilović; R Hodžić; L Kovačević; S Hodžić

doi:10.1016/j.mehy.2020.109683

Hyperkalemic periodic paralysis aggravated by voltage - gate sodium channel blocker antiepileptic drug?

Med Hypotheses. 2020 Jun:139:109683. doi: 10.1016/j.mehy.2020.109683. Epub 2020 Mar 19.

Authors

S Zukić¹, O Sinanović², M Alečković-Halilović³, R Hodžić⁴, L Kovačević⁴, S Hodžić⁵

Affiliations

¹ Department of Neurology, University Clinical Centre Tuzla, Bosnia and Herzegovina. Electronic address: sanela.zukic@ukctuzla.ba.
² Medical Faculty, University of Tuzla, Bosnia and Herzegovina. Electronic address: osman.sinanovic@untz.ba.
³ Department of Nephrology, Dialysis and Renal Transplantation, Clinic for Internal Diseases, University Clinical Centre Tuzla, Bosnia and Herzegovina.
⁴ Department of Neurology, University Clinical Centre Tuzla, Bosnia and Herzegovina.
⁵ Clinic for Internal Diseases, University Clinical Centre Tuzla, Bosnia and Herzegovina.

PMID: 32248037
DOI: 10.1016/j.mehy.2020.109683

Abstract

Hyperkalemic periodic paralysis (hyperkalemic PP) is a rare muscle disease that has onset in infancy or early childhood and is manifested by transient episodes of paralysis. In this case we presented a young male adult with attacks of weakness, after commencement of the antiepileptic drug - Carbamazepine. We hypothesize that Carbamazepine, as voltage-gate sodium channel blocker, aggravated the symptoms of hyperkalemic PP, as sodium channelopathies, in this young-male-patient, trough influence on membrane depolarization.

Keywords: Carbamazepine; HPP; Hyperkalemic periodic paralysis; Voltage-gate sodium channel blocker.

MeSH terms

Adult
Anticonvulsants* / adverse effects
Child
Child, Preschool
Humans
Male
Muscular Diseases*
Mutation
Paralysis, Hyperkalemic Periodic*
Sodium Channel Blockers

Substances

Anticonvulsants
Sodium Channel Blockers