Prurigo nodularis: Pathogenesis and management

Kyle A Williams; Amy H Huang; Micah Belzberg; Shawn G Kwatra

doi:10.1016/j.jaad.2020.04.182

Prurigo nodularis: Pathogenesis and management

J Am Acad Dermatol. 2020 Dec;83(6):1567-1575. doi: 10.1016/j.jaad.2020.04.182. Epub 2020 May 24.

Authors

Kyle A Williams¹, Amy H Huang², Micah Belzberg¹, Shawn G Kwatra³

Affiliations

¹ Department of Dermatology, Johns Hopkins University School of Medicine, Baltimore, Maryland.
² Department of Dermatology, Johns Hopkins University School of Medicine, Baltimore, Maryland; Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland.
³ Department of Dermatology, Johns Hopkins University School of Medicine, Baltimore, Maryland; Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland. Electronic address: skwatra1@jhmi.edu.

PMID: 32461078
DOI: 10.1016/j.jaad.2020.04.182

Abstract

Prurigo nodularis is a chronic skin condition characterized by severely pruritic nodules that cause a profound negative impact on quality of life. The second article in this 2-part continuing medical education series focuses on reviewing the pathogenesis of prurigo nodularis and exploring management algorithms for this condition. In addition, we discuss some emerging and novel therapies for treating prurigo nodularis. The first article in this 2-part series describes the broader epidemiology, patient demographics, physical examination findings, and symptoms to aid in the timely recognition and diagnosis of prurigo nodularis.

Keywords: antipruritic; clinical features; itch; management; pathogenesis; prurigo nodularis; pruritus; therapeutics.

Publication types

Review

MeSH terms

Administration, Cutaneous
Administration, Oral
Antidepressive Agents / administration & dosage
Antipruritics / administration & dosage
Biopsy
Calcitonin Gene-Related Peptide / metabolism
Chronic Disease / psychology
Chronic Disease / therapy
Diagnosis, Differential
Humans
Immunosuppressive Agents / administration & dosage
Medical History Taking
Nerve Tissue Proteins / metabolism
Neural Pathways / immunology
Phototherapy / methods
Prurigo / diagnosis
Prurigo / etiology*
Prurigo / psychology
Prurigo / therapy*
Randomized Controlled Trials as Topic
Receptors, Nerve Growth Factor / metabolism
Severity of Illness Index
Skin / immunology
Skin / innervation
Skin / pathology
Substance P / metabolism
Therapies, Investigational / methods
Treatment Outcome

Substances

Antidepressive Agents
Antipruritics
Immunosuppressive Agents
NGFR protein, human
Nerve Tissue Proteins
Receptors, Nerve Growth Factor
Substance P
Calcitonin Gene-Related Peptide