ALKBH1 deficiency leads to loss of homeostasis in human diploid somatic cells

Hongyu Li; Zeming Wu; Xiaoqian Liu; Sheng Zhang; Qianzhao Ji; Xiaoyu Jiang; Zunpeng Liu; Si Wang; Jing Qu; Weiqi Zhang; Moshi Song; Eli Song; Guang-Hui Liu

doi:10.1007/s13238-020-00744-4

ALKBH1 deficiency leads to loss of homeostasis in human diploid somatic cells

Protein Cell. 2020 Sep;11(9):688-695. doi: 10.1007/s13238-020-00744-4.

Authors

Hongyu Li^{1

2}, Zeming Wu^{3

2}, Xiaoqian Liu^{3

4}, Sheng Zhang^{1

2}, Qianzhao Ji^{5

2}, Xiaoyu Jiang^{5

2}, Zunpeng Liu^{3

2}, Si Wang^{5

2}, Jing Qu^{3

4

2}, Weiqi Zhang^{1

4

2

6}, Moshi Song^{7

8

9}, Eli Song^{10

11}, Guang-Hui Liu^{12

13

14

15

16}

Affiliations

¹ National Laboratory of Biomacromolecules, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, 100101, China.
² University of Chinese Academy of Sciences, Beijing, 100049, China.
³ State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, 100101, China.
⁴ Institute for Stem Cell and Regeneration, Chinese Academy of Sciences, Beijing, 100101, China.
⁵ State Key Laboratory of Membrane Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, 100101, China.
⁶ Advanced Innovation Center for Human Brain Protection, National Clinical Research Center for Geriatric Disorders, Xuanwu Hospital Capital Medical University, Beijing, 100053, China.
⁷ State Key Laboratory of Membrane Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, 100101, China. songmoshi@ioz.ac.cn.
⁸ Institute for Stem Cell and Regeneration, Chinese Academy of Sciences, Beijing, 100101, China. songmoshi@ioz.ac.cn.
⁹ University of Chinese Academy of Sciences, Beijing, 100049, China. songmoshi@ioz.ac.cn.
¹⁰ National Laboratory of Biomacromolecules, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, 100101, China. songali@ibp.ac.cn.
¹¹ University of Chinese Academy of Sciences, Beijing, 100049, China. songali@ibp.ac.cn.
¹² National Laboratory of Biomacromolecules, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, 100101, China. ghliu@ioz.ac.cn.
¹³ State Key Laboratory of Membrane Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, 100101, China. ghliu@ioz.ac.cn.
¹⁴ Institute for Stem Cell and Regeneration, Chinese Academy of Sciences, Beijing, 100101, China. ghliu@ioz.ac.cn.
¹⁵ University of Chinese Academy of Sciences, Beijing, 100049, China. ghliu@ioz.ac.cn.
¹⁶ Advanced Innovation Center for Human Brain Protection, National Clinical Research Center for Geriatric Disorders, Xuanwu Hospital Capital Medical University, Beijing, 100053, China. ghliu@ioz.ac.cn.

No abstract available

Publication types

Letter
Research Support, Non-U.S. Gov't

MeSH terms

AlkB Homolog 1, Histone H2a Dioxygenase / deficiency*
AlkB Homolog 1, Histone H2a Dioxygenase / metabolism
Cell Line
Homeostasis*
Human Embryonic Stem Cells / metabolism*
Humans

Substances

ALKBH1 protein, human
AlkB Homolog 1, Histone H2a Dioxygenase