Wilms Tumor: Challenges and Newcomers in Prognosis

Surg Pathol Clin. 2020 Dec;13(4):683-693. doi: 10.1016/j.path.2020.08.007.

Abstract

Wilms tumor is the most common renal tumor of childhood. It is a biologically and morphologically diverse entity, with ongoing studies contributing to our understanding of the pathobiology of various subgroups of patients with Wilms tumor. The interplay of histologic examination and molecular interrogation is integral in prognostication and direction of therapy. This review provides an overview of some of the challenging aspects and pitfalls in pathologic assessment of Wilms tumor, along with discussion of current and up-and-coming markers of biological behavior with prognostic significance.

Keywords: Biomarkers; Children’s oncology group; International Society of Pediatric Oncology; Wilms tumor.

Publication types

  • Review

MeSH terms

  • Biomarkers, Tumor
  • Child
  • Humans
  • Kidney Neoplasms / diagnosis
  • Kidney Neoplasms / pathology*
  • Neoplasm Staging
  • Prognosis
  • Wilms Tumor / diagnosis
  • Wilms Tumor / pathology*

Substances

  • Biomarkers, Tumor