We herein report the case of a 54-year-old male patient with a human immunodeficiency virus 1 (HIV-1) infection, usually with low viral loads and CD4 cells < 200-100/mm3 due to thymic exhaustion. He was referred to our clinic because of hypertransaminasemia and cholestasis of a duration of 58 months and liver cirrhosis on FibroScan® without esophageal varices. Nonspecific manifestations included weight loss. Liver disease stigmata and generalized amyotrophy were also present.