Extracellular vesicles in immunomodulation and tumor progression

Carolyn Marar; Bartholomew Starich; Denis Wirtz

doi:10.1038/s41590-021-00899-0

Extracellular vesicles in immunomodulation and tumor progression

Nat Immunol. 2021 May;22(5):560-570. doi: 10.1038/s41590-021-00899-0. Epub 2021 Mar 22.

Authors

Carolyn Marar^#^{1

2

3}, Bartholomew Starich^#^{1

4}, Denis Wirtz^{5

6

7

8}

Affiliations

¹ Institute for NanoBiotechnology (INBT), The Johns Hopkins University, Baltimore, MD, USA.
² Department of Biomedical Engineering, The Johns Hopkins University, Baltimore, MD, USA.
³ Biomedical Engineering Department, Boston University, Boston, MA, USA.
⁴ Department of Chemical and Biomolecular Engineering, The Johns Hopkins University, Baltimore, MD, USA.
⁵ Institute for NanoBiotechnology (INBT), The Johns Hopkins University, Baltimore, MD, USA. wirtz@jhu.edu.
⁶ Department of Chemical and Biomolecular Engineering, The Johns Hopkins University, Baltimore, MD, USA. wirtz@jhu.edu.
⁷ Departments of Oncology and Pathology, Sidney Kimmel Cancer Center, The Johns Hopkins University School of Medicine, Baltimore, MD, USA. wirtz@jhu.edu.
⁸ Johns Hopkins Physical Sciences Oncology Center, The Johns Hopkins University, Baltimore, MD, USA. wirtz@jhu.edu.

^# Contributed equally.

Abstract

Extracellular vesicles have emerged as prominent regulators of the immune response during tumor progression. EVs contain a diverse repertoire of molecular cargo that plays a critical role in immunomodulation. Here, we identify the role of EVs as mediators of communication between cancer and immune cells. This expanded role of EVs may shed light on the mechanisms behind tumor progression and provide translational diagnostic and prognostic tools for immunologists.

Publication types

Research Support, N.I.H., Extramural
Review

MeSH terms

Animals
Disease Progression
Extracellular Vesicles / immunology*
Extracellular Vesicles / metabolism
Extracellular Vesicles / pathology
Humans
Immunotherapy
Neoplasms / immunology*
Neoplasms / metabolism
Neoplasms / pathology
Neoplasms / therapy
Signal Transduction
Tumor Escape*
Tumor Microenvironment

Abstract

Publication types

MeSH terms

Grants and funding