Clinical and translational insights on premature ventricular contractions and PVC-induced cardiomyopathy

Prog Cardiovasc Dis. 2021 May-Jun:66:17-27. doi: 10.1016/j.pcad.2021.04.001. Epub 2021 Apr 20.

Abstract

The medical community's understanding of the consequences of premature ventricular contractions (PVCs) and PVC-induced cardiomyopathy has been derived mostly from observational and large population-based studies. Due to the difficulty of predicting the development of PVC-cardiomyopathy, the acute and chronic cardiac effects of PVCs and the mechanism of PVC-cardiomyopathy have been derived from pre-clinical studies with large animal models. Recently, these studies have described myocardial substrates that could potentially increase morbidity and mortality in patients with frequent PVCs and PVC-cardiomyopathy. In this paper, we provide an up-to-date comprehensive review of these pre-clinical and clinical studies.

Keywords: Eccentric hypertrophy; Heart rate irregularity; LV dyssynchrony; Premature atrial contraction; Premature ventricular contraction.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Review

MeSH terms

  • Action Potentials
  • Animals
  • Cardiomyopathies* / diagnosis
  • Cardiomyopathies* / epidemiology
  • Cardiomyopathies* / physiopathology
  • Cardiomyopathies* / therapy
  • Heart Conduction System / physiopathology
  • Heart Rate
  • Humans
  • Prevalence
  • Prognosis
  • Risk Factors
  • Translational Research, Biomedical
  • Ventricular Premature Complexes* / diagnosis
  • Ventricular Premature Complexes* / epidemiology
  • Ventricular Premature Complexes* / physiopathology
  • Ventricular Premature Complexes* / therapy