MCP-1: Function, regulation, and involvement in disease

Int Immunopharmacol. 2021 Dec;101(Pt B):107598. doi: 10.1016/j.intimp.2021.107598. Epub 2021 May 20.

Abstract

MCP-1 (Monocyte chemoattractant protein-1), also known as Chemokine (CC-motif) ligand 2 (CCL2), is from family of CC chemokines. It has a vital role in the process of inflammation, where it attracts or enhances the expression of other inflammatory factors/cells. It leads to the advancement of many disorders by this main mechanism of migration and infiltration of inflammatory cells like monocytes/macrophages and other cytokines at the site of inflammation. MCP-1 has been inculpated in the pathogenesis of numerous disease conditions either directly or indirectly like novel corona virus, cancers, neuroinflammatory diseases, rheumatoid arthritis, cardiovascular diseases. The elevated MCP-1 level has been observed in COVID-19 patients and proven to be a biomarker associated with the extremity of disease along with IP-10. This review will focus on involvement and role of MCP-1 in various pathological conditions.

Keywords: CCL2; COVID-19; Cancer; Endothelial dysfunction; Monocyte chemoattractant protein-1; NF-ĸB; Oxidative stress.

Publication types

  • Review

MeSH terms

  • Animals
  • Biomarkers
  • Chemokine CCL2 / genetics
  • Chemokine CCL2 / immunology*
  • Chemokine CCL2 / physiology
  • Chemotaxis
  • Disease
  • Humans
  • Monocytes / physiology
  • Oxidative Stress

Substances

  • Biomarkers
  • CCL2 protein, human
  • Chemokine CCL2