Diffuse Large B-Cell Lymphoma Arising in the Lacrimal Sac

The authors report a single case of diffuse large B-cell lymphoma arising in the lacrimal sac. Diffuse large B-cell lymphoma is a third most common primary ocular adnexal lymphoma, which is the most common primary ocular malignant disease in adults. A patient came to our clinic with epiphora and a growing mass in the lacrimal sac. Enhanced computed tomography imaging suggested the presence of a malignant tumor and surgical excision and biopsy were performed. A final diagnosis of diffuse large B-cell lymphoma was reached by immunohistological and immunochemical staining. Two months after surgery, diffuse large B-cell lymphoma relapse occurred in the lacrimal sac and the patient underwent 6 cycles of chemotherapy. Diffuse large B-cell lymphoma is a curable disease when diagnosed early, and aggressive biopsy during surgery of the lacrimal sac is necessary to diagnose diffuse large B-cell lymphoma in the early stage. It is important to distinguish diffuse large B-cell lymphoma from other lacrimal system diseases.