Infant Acute Leukemia

Gerald Wertheim

doi:10.1016/j.cll.2021.04.002

Infant Acute Leukemia

Clin Lab Med. 2021 Sep;41(3):541-550. doi: 10.1016/j.cll.2021.04.002.

Author

Gerald Wertheim¹

Affiliation

¹ Children's Hospital of Philadelphia, Perelman School of Medicine at the University of Pennsylvania, 5199b Main Building, 3401 Civic Center Boulevard, Philadelphia, PA 19104-4399, USA. Electronic address: wertheimg@email.chop.edu.

PMID: 34304781
DOI: 10.1016/j.cll.2021.04.002

Abstract

Infant acute leukemia is a rare but aggressive disease. Although infant acute leukemia is cytologically and histologically similar to acute leukemia seen in older children and adults, it displays unique and characteristic clinical and genetic characteristics. The features, as well as the extremely young age of the patients, present multiple challenges for treatment. This review focuses on the unique pathology of acute leukemia of infancy, including the genetic characteristics that are specific for these diseases.

Keywords: Acute leukemia; Acute megakaryoblastic leukemia; Infants; Transient myelopoiesis of Down syndrome.

Publication types

Review

MeSH terms

Acute Disease
Adult
Child
Down Syndrome*
Humans
Infant
Leukemia* / diagnosis
Leukemia* / genetics
Leukemia, Megakaryoblastic, Acute*