Up-Regulated LncRNA FEZF1-AS1 Promotes the Progression of Cervical Carcinoma Cells via MiR-367-3p/SLC12A5 Signal Axis

Background: Cervical cancer (CC) is a common female malignant tumor. With the trend of younger onset, people pay more and more attention to it. Numberless evidence has been indicated that long non-coding RNAs (lncRNAs) can take part in progression of cancers and can exert the regulatory roles in assorted cancers. Nevertheless, the roles of FEZ family zinc finger 1-antisense RNA 1 (FEZF1-AS1) in CC cells are still undiscovered.

Aim of the study: Thus, the central purpose of our research was to reveal the specific functions and molecular mechanisms of FEZF1-AS1 in CC cells.

Methods: RT-qPCR was utilized to test FEZF1-AS1 expression in CC cells. In addition, functional assays were conducted to evaluate cell proliferation, apoptosis, and migration as well as invasion. In addition, mechanism experiments verified relationship among FEZF1-AS1, miR-367-3p and solute carrier family 12 member 5 (SLC12A5).

Results: FEZF1-AS1 was highly expressed in CC cells. Moreover, FEZF1-AS1 depletion suppressed proliferation, migration, invasion, and induced cell apoptosis. Importantly, mechanism experiments confirmed that miR-367-3p could bissnd to FEZF1-AS1 and SLC12A5. The rescue assays determined that FEZF1-AS1 could up-regulate SLC12A5 through binding to miR-367-3p.

Conclusions: The up-regulated FEZF1-AS1 could accelerate the malignant behaviors of CC cells by miR-367-3p/SLC12A5 signal axis.