CRS is a benign, self-limited process that has an excellent prognosis for immediate and rapid recovery. While questions remain about exactly who is susceptible, how much MSG is needed, and even whether MSG is the sole etiologic agent, there appears to be little reason to embark on an extensive workup and treatment regimen with a presumptive diagnosis of MSG intoxication. Rather, knowledge of CRS and recognition of its associated signs and symptoms and its clinical course are important.