A Clinical Study of Cirrhosis with Special Reference to Thyroid Function

It is known that impaired thyroid function affects liver function and similarly liver disorders, also affect thyroid function. In this study, we looked at the clinical profile of cirrhosis and studied the correlation between cirrhosis and thyroid function.

Material: The study was conducted as an observational cross-sectional study on patients with cirrhosis of liver reporting at the Department of Medicine, SSMC Rewa (M.P.) during the study period of 15 months i.e. from 1st April 2020 to 30th June 2021. Detailed history regarding risk factors, duration of liver disease, history pertaining to its etiology was obtained. The severity of liver disease was assessed using the Child-Pugh score. All the patients were then subjected to relevant investigations including Serum T3, T4, TSH.

Observation: A total of 100 cases of liver cirrhosis were enrolled in our study with a mean age of 53.26±12.54 years. We observed a statistically significant association of Child Pugh Score with T3, T4 as well as TSH (p<0.05). We observed a moderate correlation of Child-Pugh score with T3 levels and TSH (r=0.452 and 0.311 respectively; p<0.05), and a weak correlation was observed with T4 (r=0.240; p<0.05).

Conclusion: In cirrhosis of the liver majority of subjects show impaired thyroid functions. Thyroid hormone levels help assess the severity as well as the course of cirrhosis and among T3, T4, TSH values, Total T3 is considered as a better predictor of severity of cirrhosis.