A Critical Overview of Targeted Therapies for Vestibular Schwannoma

Int J Mol Sci. 2022 May 13;23(10):5462. doi: 10.3390/ijms23105462.

Abstract

Vestibular schwannoma (VS) is a benign tumor that originates from Schwann cells in the vestibular component. Surgical treatment for VS has gradually declined over the past few decades, especially for small tumors. Gamma knife radiosurgery has become an accepted treatment for VS, with a high rate of tumor control. For neurofibromatosis type 2 (NF2)-associated VS resistant to radiotherapy, vascular endothelial growth factor (VEGF)-A/VEGF receptor (VEGFR)-targeted therapy (e.g., bevacizumab) may become the first-line therapy. Recently, a clinical trial using a VEGFR1/2 peptide vaccine was also conducted in patients with progressive NF2-associated schwannomas, which was the first immunotherapeutic approach for NF2 patients. Targeted therapies for the gene product of SH3PXD2A-HTRA1 fusion may be effective for sporadic VS. Several protein kinase inhibitors could be supportive to prevent tumor progression because merlin inhibits signaling by tyrosine receptor kinases and the activation of downstream pathways, including the Ras/Raf/MEK/ERK and PI3K/Akt/mTORC1 pathways. Tumor-microenvironment-targeted therapy may be supportive for the mainstays of management. The tumor-associated macrophage is the major component of immunosuppressive cells in schwannomas. Here, we present a critical overview of targeted therapies for VS. Multimodal therapy is required to manage patients with refractory VS.

Keywords: NF2; SH3PXD2A-HTRA1 fusion; VEGF; bevacizumab; molecular targeted therapy; schwannoma.

Publication types

  • Review

MeSH terms

  • High-Temperature Requirement A Serine Peptidase 1
  • Humans
  • Neurilemmoma* / metabolism
  • Neurofibromatosis 2*
  • Neuroma, Acoustic* / genetics
  • Neuroma, Acoustic* / therapy
  • Phosphatidylinositol 3-Kinases
  • Tumor Microenvironment
  • Vascular Endothelial Growth Factor A

Substances

  • Vascular Endothelial Growth Factor A
  • High-Temperature Requirement A Serine Peptidase 1
  • HTRA1 protein, human

Grants and funding

This research received no external funding.