Nanotherapeutic treatment of the invasive glioblastoma tumor microenvironment

Nikhil Pandey; Pavlos Anastasiadis; Christine P Carney; Pranjali P Kanvinde; Graeme F Woodworth; Jeffrey A Winkles; Anthony J Kim

doi:10.1016/j.addr.2022.114415

Nanotherapeutic treatment of the invasive glioblastoma tumor microenvironment

Adv Drug Deliv Rev. 2022 Sep:188:114415. doi: 10.1016/j.addr.2022.114415. Epub 2022 Jul 3.

Authors

Nikhil Pandey¹, Pavlos Anastasiadis¹, Christine P Carney¹, Pranjali P Kanvinde¹, Graeme F Woodworth², Jeffrey A Winkles³, Anthony J Kim⁴

Affiliations

¹ Department of Neurosurgery, University of Maryland School of Medicine, Baltimore, MD 21201, United States; Marlene and Stewart Greenebaum Comprehensive Cancer Center, University of Maryland School of Medicine, Baltimore, MD 21201, United States.
² Department of Neurosurgery, University of Maryland School of Medicine, Baltimore, MD 21201, United States; Marlene and Stewart Greenebaum Comprehensive Cancer Center, University of Maryland School of Medicine, Baltimore, MD 21201, United States; Fischell Department of Bioengineering, A. James Clarke School of Engineering, University of Maryland, College Park, MD, 20742, United States.
³ Department of Neurosurgery, University of Maryland School of Medicine, Baltimore, MD 21201, United States; Marlene and Stewart Greenebaum Comprehensive Cancer Center, University of Maryland School of Medicine, Baltimore, MD 21201, United States; Department of Surgery, University of Maryland School of Medicine, Baltimore, MD 21201, United States; Center for Vascular and Inflammatory Diseases, University of Maryland School of Medicine, Baltimore, MD 21201, United States. Electronic address: jwinkles@som.umaryland.edu.
⁴ Department of Neurosurgery, University of Maryland School of Medicine, Baltimore, MD 21201, United States; Marlene and Stewart Greenebaum Comprehensive Cancer Center, University of Maryland School of Medicine, Baltimore, MD 21201, United States; Department of Pharmacology, University of Maryland School of Medicine, Baltimore, MD 21201, United States; Department of Pharmaceutical Sciences, University of Maryland School of Pharmacy, Baltimore, MD 21201, United States; Fischell Department of Bioengineering, A. James Clarke School of Engineering, University of Maryland, College Park, MD, 20742, United States. Electronic address: akim@som.umaryland.edu.

Abstract

Glioblastoma (GBM) is the most common malignant adult brain cancer with no curative treatment strategy. A significant hurdle in GBM treatment is effective therapeutic delivery to the brain-invading tumor cells that remain following surgery within functioning brain regions. Developing therapies that can either directly target these brain-invading tumor cells or act on other cell types and molecular processes supporting tumor cell invasion and recurrence are essential steps in advancing new treatments in the clinic. This review highlights some of the drug delivery strategies and nanotherapeutic technologies that are designed to target brain-invading GBM cells or non-neoplastic, invasion-supporting cells residing within the GBM tumor microenvironment.

Keywords: Blood–brain barrier; Brain invasion; Focused ultrasound; Glioblastoma; High-grade glioma; Nanoparticles; Tumor microenvironment.

Publication types

Review

MeSH terms

Adult
Brain / metabolism
Brain Neoplasms* / drug therapy
Brain Neoplasms* / metabolism
Drug Delivery Systems
Glioblastoma* / drug therapy
Humans
Tumor Microenvironment

Abstract

Publication types

MeSH terms

Grants and funding