Histone demethylase KDM2A suppresses EGF-TSPAN8 pathway to inhibit breast cancer cell migration and invasion in vitro

Biochem Biophys Res Commun. 2022 Nov 5:628:104-109. doi: 10.1016/j.bbrc.2022.08.057. Epub 2022 Aug 30.

Abstract

Metastasis is a major cause of breast cancer mortality and the current study found histone demethylase, KDM2A, expression to be negatively correlated with breast cancer metastasis. KDM2A knockdown greatly promoted migration and invasion of breast cancer cells. The histone demethylase activity of KDM2A downregulated EGF transcription and suppressed the EGF-TSPAN8 pathway. Inhibition of breast cancer cell migration was also dependent on the histone demethylase activity of KDM2A. A novel mechanism of KDM2A-suppression of the EGF-TSPAN8 pathway which inhibited breast cancer cell migration and invasion is reported.

Keywords: Breast cancer; EGF; Invasion; KDM2A; Migration; TSPAN8.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Breast Neoplasms* / genetics
  • Breast Neoplasms* / pathology
  • Cell Line, Tumor
  • Cell Movement / genetics
  • Cell Proliferation / genetics
  • Cell Proliferation / physiology
  • Epidermal Growth Factor / metabolism
  • Epidermal Growth Factor / pharmacology
  • F-Box Proteins* / genetics
  • F-Box Proteins* / metabolism
  • Female
  • Gene Expression Regulation, Neoplastic
  • Histone Demethylases / genetics
  • Histone Demethylases / metabolism
  • Humans
  • Jumonji Domain-Containing Histone Demethylases* / metabolism
  • Tetraspanins / metabolism

Substances

  • F-Box Proteins
  • TSPAN8 protein, human
  • Tetraspanins
  • Epidermal Growth Factor
  • Histone Demethylases
  • Jumonji Domain-Containing Histone Demethylases
  • KDM2A protein, human