Development and validation of a prognostic nomogram for adult patients with renal sarcoma: A retrospective study based on the SEER database

Yongkun Zhu; Weipu Mao; Guangyuan Zhang; Si Sun; Shuchun Tao; Tiancheng Jiang; Qingbo Wang; Yuan Meng; Jianping Wu; Ming Chen

doi:10.3389/fpubh.2022.942608

Development and validation of a prognostic nomogram for adult patients with renal sarcoma: A retrospective study based on the SEER database

Front Public Health. 2022 Sep 12:10:942608. doi: 10.3389/fpubh.2022.942608. eCollection 2022.

Authors

Yongkun Zhu^{1

2}, Weipu Mao¹, Guangyuan Zhang¹, Si Sun^{1

2}, Shuchun Tao², Tiancheng Jiang², Qingbo Wang³, Yuan Meng⁴, Jianping Wu¹, Ming Chen¹

Affiliations

¹ Department of Urology, Affiliated Zhongda Hospital of Southeast University, Nanjing, China.
² Department of Medical College, Southeast University, Nanjing, China.
³ Department of Chemotherapy, Affiliated the Second Hospital of Nanjing, Nanjing University of Chinese Medicine, Nanjing, China.
⁴ Department of Urology, Nanjing Lishui People's Hospital, Zhongda Hospital Lishui Branch of Southeast University, Nanjing, China.

Abstract

Background: Renal sarcoma (RS) is rarely seen in clinical practice. The purpose of this study was to develop a prognostic nomogram model, which could predict the probability of overall survival (OS) and cancer-specific survival (CSS) in adult patients with RS.

Methods: Patients diagnosed with RS were recruited from the SEER database between 2004 and 2015, and randomized to two cohorts: the training cohort and the validation cohort. Uni- and multivariate Cox regression analyses in the training cohort were used to screen independent prognostic factors for OS and CSS. Prognostic nomograms for OS and CSS were created separately for adult RS patients based on independent risk factors. The area under the receiver operating characteristic (ROC) curves, calibration curves, and decision curve analysis (DCA) were used to validate the nomograms.

Results: A total of 232 eligible patients were recruited, including 162 in the training cohort and 70 in the validation cohort. Sex, histological type, SEER stage, and surgery were independent prognostic factors for OS, while histological type, SEER stage, surgery, chemotherapy were independent prognostic factors for CSS. Based on the above independent prognostic factors, prognostic nomograms for OS and CSS were created respectively. In the training cohort, the AUCs of the nomograms for OS and CSS were 0.742 and 0.733, respectively. In the validation cohort, the AUCs of the nomograms for OS and CSS were 0.837 and 0.758, respectively. The calibration curves of the nomograms showed high consistencies between the predicted and actual survival rates. Finally, the DCA demonstrated that the nomograms in the wide high-risk threshold had a higher net benefit than the SEER stage.

Conclusion: A prognostic nomogram for renal sarcoma was created and validated for reliability and usefulness in our study, which assisted urologists in accurately assessing the prognosis of adult RS patients.

Keywords: SEER; adult patients; nomogram; prognosis; renal sarcoma.

Publication types

Randomized Controlled Trial
Research Support, Non-U.S. Gov't

MeSH terms

Adult
Humans
Neoplasm Staging
Nomograms*
Prognosis
Reproducibility of Results
Retrospective Studies
Risk Factors
SEER Program
Sarcoma* / diagnosis
Sarcoma* / epidemiology