Medical Treatment of Vascular Anomalies

Dermatol Clin. 2022 Oct;40(4):461-471. doi: 10.1016/j.det.2022.06.013.

Abstract

The treatment of vascular malformations and vascular anomalies is often complex, combining various approaches in the art of medicine to provide best outcomes and quality of life for these patients. Treatment may include but is not limited to the following: local control with compression garments and attire, pain control, surgical procedures and debulking, laser therapy, sclerotherapy, and medical management. In this article, the authors discuss the aspects of medical management, visiting the history of medical treatment, and the recent utilization and success of enzymatic pathway inhibitors, specifically sirolimus and new therapies that hold promise for the future for these patients.

Keywords: Sirolimus; Vascular anomaly(ies) (VAs); Vascular malformation (VascM); mTOR.

Publication types

  • Review

MeSH terms

  • Humans
  • Quality of Life*
  • Sirolimus / adverse effects
  • Treatment Outcome
  • Vascular Malformations* / therapy

Substances

  • Sirolimus