Dietary Treatments for Epilepsy

Babitha Haridas; Eric H Kossoff

doi:10.1016/j.ncl.2022.03.009

Dietary Treatments for Epilepsy

Neurol Clin. 2022 Nov;40(4):785-797. doi: 10.1016/j.ncl.2022.03.009. Epub 2022 Sep 28.

Authors

Babitha Haridas¹, Eric H Kossoff²

Affiliations

¹ Departments of Neurology and Pediatrics, Johns Hopkins University, Johns Hopkins Hospital, Suite 2158, 200 North Wolfe Street, Baltimore, MD 21287, USA. Electronic address: bharida1@jh.edu.
² Departments of Neurology and Pediatrics, Johns Hopkins University, Johns Hopkins Hospital, Suite 2158, 200 North Wolfe Street, Baltimore, MD 21287, USA.

PMID: 36270691
DOI: 10.1016/j.ncl.2022.03.009

Abstract

The ketogenic diet is one of the four major treatments for epilepsy, along with antiseizure medications, neuromodulation, and surgery. Ketogenic diet therapy has been proven to be a safe and effective antiseizure regimen for a century. There are multiple methods to administer the diet and the initiation should be individualized for each patient. The diet has been shown to be an effective treatment of choice for Glut1 deficiency, pyruvate dehydrogenase deficiency, infantile spasms, and superrefractory status epilepticus among others. This review discusses the administration of ketogenic diet therapy and highlights its role for specific epilepsy syndromes.

Keywords: Epilepsy; Glut1 deficiency; Ketogenic diet; Ketosis; Refractory.

Publication types

Review

MeSH terms

Carbohydrate Metabolism, Inborn Errors*
Diet
Diet, Ketogenic*
Epilepsy* / drug therapy
Glucose Transporter Type 1
Humans
Ketone Bodies / therapeutic use
Treatment Outcome

Substances

Glucose Transporter Type 1
Ketone Bodies