Insulin-like Growth Factor-2 (IGF-2) in Fibrosis

Biomolecules. 2022 Oct 25;12(11):1557. doi: 10.3390/biom12111557.

Abstract

The insulin family consists of insulin, insulin-like growth factor 1 (IGF-1), insulin-like growth factor 2 (IGF-2), their receptors (IR, IGF-1R and IGF-2R), and their binding proteins. All three ligands are involved in cell proliferation, apoptosis, protein synthesis and metabolism due to their homologous sequences and structural similarities. Insulin-like growth factor 2, a member of the insulin family, plays an important role in embryonic development, metabolic disorders, and tumorigenesis by combining with three receptors with different degrees of affinity. The main pathological feature of various fibrotic diseases is the excessive deposition of extracellular matrix (ECM) after tissue and organ damage, which eventually results in organic dysfunction because scar formation replaces tissue parenchyma. As a mitogenic factor, IGF-2 is overexpressed in many fibrotic diseases. It can promote the proliferation of fibroblasts significantly, as well as the production of ECM in a time- and dose-dependent manner. This review aims to describe the expression changes and fibrosis-promoting effects of IGF-2 in the skin, oral cavity, heart, lung, liver, and kidney fibrotic tissues.

Keywords: IGF-1R; IR; extracellular matrix (ECM); fibrosis; insulin-like growth factor 2 (IGF-2).

Publication types

  • Review
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Extracellular Matrix / metabolism
  • Fibrosis
  • Humans
  • Insulin / metabolism
  • Insulin-Like Growth Factor II* / genetics
  • Insulin-Like Growth Factor II* / metabolism
  • Receptor, Insulin* / metabolism

Substances

  • Insulin-Like Growth Factor II
  • Receptor, Insulin
  • Insulin

Grants and funding

This work was supported by grants from the National Natural Science Foundation of China (grant number 82002061 and 82072182).