ATM Regulation of the Cohesin Complex Is Required for Repression of DNA Replication and Transcription in the Vicinity of DNA Double-Strand Breaks

Mol Cancer Res. 2023 Mar 1;21(3):261-273. doi: 10.1158/1541-7786.MCR-22-0399.

Abstract

Multiple members of the cohesin complex are involved in the regulation of DNA replication and transcription in the vicinity of DNA double-strand breaks and their role(s) are regulated by the ATM kinase.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Ataxia Telangiectasia Mutated Proteins / genetics
  • Ataxia Telangiectasia Mutated Proteins / metabolism
  • Cell Cycle Proteins* / genetics
  • Cell Cycle Proteins* / metabolism
  • Cohesins
  • DNA / metabolism
  • DNA Replication*
  • Humans
  • Phosphorylation

Substances

  • Ataxia Telangiectasia Mutated Proteins
  • Cell Cycle Proteins
  • DNA
  • ATM protein, human