Synergistic immunotherapy targeting cancer-associated anemia: prospects of a combination strategy

Cell Commun Signal. 2023 May 19;21(1):117. doi: 10.1186/s12964-023-01145-w.

Abstract

Cancer-associated anemia promotes tumor progression, leads to poor quality of life in patients with cancer, and even obstructs the efficacy of immune checkpoint inhibitors therapy. However, the precise mechanism for cancer-associated anemia remains unknown and the feasible strategy to target cancer-associated anemia synergizing immunotherapy needs to be clarified. Here, we review the possible mechanisms of cancer-induced anemia regarding decreased erythropoiesis and increased erythrocyte destruction, and cancer treatment-induced anemia. Moreover, we summarize the current paradigm for cancer-associated anemia treatment. Finally, we propose some prospective paradigms to slow down cancer-associated anemia and synergistic the efficacy of immunotherapy. Video Abstract.

Keywords: Cancer-associated anemia; Eryptosis; Erythropoiesis; Extramedullary hematopoiesis; Immune checkpoint inhibitors.

Publication types

  • Video-Audio Media
  • Review
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anemia* / complications
  • Anemia* / therapy
  • Humans
  • Immunotherapy
  • Neoplasms* / complications
  • Neoplasms* / therapy
  • Prospective Studies
  • Quality of Life