A case report of recurrent leiomyosarcoma with chondrosarcoma differentiation in the abdominal wall and a review of the literature

Xuan Zuo; Wei L Wu; Peng Shi; Tian M Liu; Na Yu; Lei Li

doi:10.3389/pore.2023.1611109

A case report of recurrent leiomyosarcoma with chondrosarcoma differentiation in the abdominal wall and a review of the literature

Pathol Oncol Res. 2023 May 10:29:1611109. doi: 10.3389/pore.2023.1611109. eCollection 2023.

Authors

Xuan Zuo^{1

2}, Wei L Wu^{1

2}, Peng Shi^{1

2}, Tian M Liu^{1

2}, Na Yu^{1

2}, Lei Li^{1

2}

Affiliations

¹ Department of Pathology, West China Second University Hospital, Sichuan University, Chengdu, China.
² Key Laboratory of Birth Defects and Related Diseases of Women and Children, Ministry of Education, Sichuan University, Chengdu, China.

Abstract

Leiomyosarcoma with heterologous differentiation is relatively rare. To date, only 19 cases have been reported in the English literature. Heterologous components frequently show histological pleomorphism, while those exhibiting well-differentiated morphology are seldom reported. Here, we report a 34-year-old female diagnosed with leiomyosarcoma and developed abdominal wall recurrence 8 years after primary surgery. The recurrent tumor mainly comprised well-differentiated chondrosarcoma except a single focus of leiomyosarcoma. Due to the rarity and prolonged onset of such a transition, our case provides insight into the understanding of this phenomenon.

Keywords: case report; chondrosarcoma; heterologous differentiation; leiomyosarcoma; recurrence.

Publication types

Review
Case Reports

MeSH terms

Abdominal Wall* / pathology
Abdominal Wall* / surgery
Adult
Bone Neoplasms* / surgery
Chondrosarcoma* / pathology
Chondrosarcoma* / surgery
Female
Humans
Leiomyosarcoma* / pathology
Leiomyosarcoma* / surgery