Intravascular Tumor Extension and Pulmonary Tumor Embolism in Children With Solid Malignancies: Is There a Role for Inferior Vena Cava Filters?

Sarah M Trinder; Sandra D Ruhayel; Nicholas G Gottardo; Clare A McLaren; Anne L Ryan; Derek J Roebuck

doi:10.1097/MPH.0000000000002731

Intravascular Tumor Extension and Pulmonary Tumor Embolism in Children With Solid Malignancies: Is There a Role for Inferior Vena Cava Filters?

J Pediatr Hematol Oncol. 2023 Nov 1;45(8):467-471. doi: 10.1097/MPH.0000000000002731. Epub 2023 Jul 27.

Authors

Sarah M Trinder¹, Sandra D Ruhayel¹, Nicholas G Gottardo¹, Clare A McLaren^{2

3}, Anne L Ryan^{1

4}, Derek J Roebuck^{2

5}

Affiliations

¹ Department of Hematology, Oncology, and Bone Marrow Transplant Perth Children's Hospital, Nedlands.
² Department of Medical Imaging, Perth Children's Hospital, Nedlands.
³ Curtin Medical School, Curtin University, Bentley.
⁴ Telethon Kids Cancer Centre, Telethon Kids Institute, Perth, WA.
⁵ Division of Pediatrics, Medical School, University of Western Australia, Crawley, Australia.

PMID: 37526419
DOI: 10.1097/MPH.0000000000002731

Abstract

Intravascular tumor extension is an uncommon complication of solid malignancies that, when present in the inferior vena cava (IVC), can result in fatal pulmonary tumor embolism. Currently, neoadjuvant chemotherapy and surgery are the mainstays of treatment; however, there are no consensus guidelines for management. We describe three cases of pediatric solid malignancies with associated IVC extension and pulmonary tumor embolism. We hypothesize that there is scope for IVC filter placement in such cases to mitigate the risk of fatal pulmonary tumor embolism.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Child
Humans
Lung Neoplasms* / complications
Lung Neoplasms* / therapy
Pulmonary Embolism* / etiology
Pulmonary Embolism* / prevention & control
Treatment Outcome
Vena Cava Filters* / adverse effects
Vena Cava, Inferior